PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth.

B, Lanske; AC, Karaplis; K, Lee; A, Luz; A, Vortkamp; A, Pirro; M, Karperien; LH, Defize; C, Ho; RC, Mulligan; AB, Abou-Samra; H, Jüppner; GV, Segre; HM, Kronenberg

doi:10.1126/science.273.5275.663

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PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth.

Shared by NobleBlocks on Aug 1, 1996 • 12:00 AM UTC

Authors:

Lanske B

Karaplis AC

Lee K

Abstract

The PTH/PTHrP receptor binds to two ligands with distinct functions: the calcium-regulating hormone, parathyroid hormone (PTH), and the paracrine factor, PTH-related protein (PTHrP). Each ligand, in turn, is likely to activate more than one receptor. The functions of the PTH/PTHrP receptor were inve...

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