Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

Huch, Meritxell; Gehart, Helmuth; van Boxtel, Ruben; M. Hamer, Karien; Blokzijl, Francis; M.A. Verstegen, Monique; Ellis, Ewa; van Wenum, Martien; A. Fuchs, Sabine; de Ligt, Joep; van de Wetering, Marc; Sasaki, Nobuo; J. Boers, Susanne; Kemperman, Hans; de Jonge, Jeroen; N.M. IJzermans, Jan; E. S. Nieuwenhuis, Edward; Hoekstra, Ruurdtje; C. Strom, Stephen; Vries, Robert; J. W. van der Laan, Luc; Cuppen, Edwin; Clevers, Hans

doi:10.1016/j.cell.2014.11.050

Public

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

Published in Cell • Dec 19, 2014

Authors:

Meritxell Huch

Helmuth Gehart

Ruben van Boxtel

Abstract

Despite the enormous replication potential of the human liver, there are currently no culture systems available that sustain hepatocyte replication and/or function in vitro. We have shown previously that single mouse Lgr5+ liver stem cells can be expanded as epithelial organoids in vitro and can be ...

Subject

Biology

Stem cell

Cell biology

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