Randomized Phase III Study of Capecitabine Plus Oxaliplatin Compared With Fluorouracil/Folinic Acid Plus Oxaliplatin As First-Line Therapy for Metastatic Colorectal Cancer

Cassidy, Jim; Clarke, Stephen; Díaz‐Rubio, Eduardo; Scheithauer, Werner; Figer, Arié; Wong, Ralph; Koski, Sheryl; Lichinitser, Mikhail; Yang, Tsai‐Shen; Rivera, Fernando; Couture, Félix; Sirzén, Florin; B. Saltz, Leonard

doi:10.1200/jco.2007.14.9898

Public

Randomized Phase III Study of Capecitabine Plus Oxaliplatin Compared With Fluorouracil/Folinic Acid Plus Oxaliplatin As First-Line Therapy for Metastatic Colorectal Cancer

Published in Journal of Clinical Oncology • Apr 17, 2008

Authors:

Jim Cassidy

Stephen Clarke

Eduardo Díaz‐Rubio

Abstract

PURPOSE: To evaluate whether capecitabine plus oxaliplatin (XELOX) is noninferior to fluorouracil. folinic acid, and oxaliplatin (FOLFOX-4) as first-line therapy in metastatic colorectal cancer (MCRC). PATIENTS AND METHODS: The initial design of this trial was a randomized, two-arm, noninferiority, ...

Subject

FOLFOX

Oxaliplatin

Medicine

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