The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system

Bradaïa, Amyaouch; Trube, Gerhard; Stalder, Henri; D. Norcross, Roger; Ozmen, Laurence; G. Wettstein, Joseph; Pinard, Audrée; Buchy, Danièle; Gassmann, Martin; C. Hoener, Marius; Bettler, Bernhard

doi:10.1073/pnas.0906522106

Public

The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system

Published in Proceedings of the National Academy of Sciences • Nov 5, 2009

Authors:

Amyaouch Bradaïa

Gerhard Trube

Henri Stalder

Abstract

Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor (GPCR) that is nonselectively activated by endogenous metabolites of amino acids. TAAR1 is considered a promising drug target for the treatment of psychiatric and neurodegenerative disorders. However, no selective ligand to id...

Subject

Dopaminergic

Ventral tegmental area

Neuroscience

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