Nitric Oxide Activity Is Deficient in Spasm Arteries of Patients With Coronary Spastic Angina

Kugiyama, Kiyotaka; Yasue, Hirofumi; Okumura, Ken; Ogawa, Hisao; Fujimoto, Kazuteru; Nakao, Koichi; Yoshimura, Michihiro; Motoyama, Takeshi; Inobe, Yoshito; Kawano, Hiroaki

doi:10.1161/01.cir.94.3.266

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Nitric Oxide Activity Is Deficient in Spasm Arteries of Patients With Coronary Spastic Angina

Shared by NobleBlocks on Aug 1, 1996 • 12:00 AM UTC

Authors:

Kiyotaka Kugiyama

Hirofumi Yasue

Ken Okumura

Abstract

Background Coronary spasm can be induced by acetylcholine, serotonin, ergonovine, or histamine, all of which cause vasodilation when the endothelium is intact by releasing nitric oxide (NO). Coronary spasm is promptly relieved by nitroglycerin, which vasodilates through its conversion to NO. It is t...

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