Interferon-γ and Tumor Necrosis Factor-α Mediate the Upregulation of Indoleamine 2,3-Dioxygenase and the Induction of Depressive-Like Behavior in Mice in Response to Bacillus Calmette-Guérin

C. O'Connor, Jason; André, Caroline; Wang, Yunxia; A. Lawson, Marcus; S. Szegedi, Sandra; Lestage, Jacques; Castanon, Nathalie; W. Kelley, Keith; Dantzer, Robert

doi:10.1523/jneurosci.5032-08.2009

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Interferon-γ and Tumor Necrosis Factor-α Mediate the Upregulation of Indoleamine 2,3-Dioxygenase and the Induction of Depressive-Like Behavior in Mice in Response to Bacillus Calmette-Guérin

Shared by NobleBlocks on Apr 1, 2009 • 12:00 AM UTC

Authors:

Jason C. O'Connor

Caroline André

Yunxia Wang

Abstract

Although the tryptophan-degrading enzyme, indoleamine 2,3-dioxygenase (IDO), is a pivotal mediator of inflammation-induced depression, its mechanism of regulation has not yet been investigated in this context. Here, we demonstrate an essential role for interferon (IFN)γ and tumor necrosis factor (TN...

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