Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape.
Published in Immunological reviews • Apr 1, 2008
Authors:,,
Jessica B Katz
Alexander J Muller
George C Prendergast
Abstract
Indoleamine 2, 3-dioxygenase (IDO) degrades the essential amino acid tryptophan in mammals, catalyzing the initial and rate-limiting step in the de novo biosynthesis nicotinamide adenine dinucleotide (NAD). Broad evidence implicates IDO and the tryptophan catabolic pathway in generation of immune to...
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