Breast and Ovarian Cancer Risks Due to Inherited Mutations in <i>BRCA1</i> and <i>BRCA2</i>

King, Mary‐Claire; H. Marks, Joan; B. Mandell, Jessica

doi:10.1126/science.1088759

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Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2

Published in Science • Oct 23, 2003

Authors:

Mary‐Claire King

Joan H. Marks

Jessica B. Mandell

Abstract

Risks of breast and ovarian cancer were determined for Ashkenazi Jewish women with inherited mutations in the tumor suppressor genes BRCA1 and BRCA2. We selected 1008 index cases, regardless of family history of cancer, and carried out molecular analysis across entire families. The lifetime risk of ...

Subject

Ovarian cancer

Breast cancer

Family history

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