Rational Design of α-Helical Antimicrobial Peptides with Enhanced Activities and Specificity/Therapeutic Index

Chen, Yuxin; T. Mant, Colin; Walker Farmer, Susan; E. W. Hancock, Robert; L. Vasil, Michael; S. Hodges, Robert

doi:10.1074/jbc.m413406200

Public

Rational Design of α-Helical Antimicrobial Peptides with Enhanced Activities and Specificity/Therapeutic Index

Published in Journal of Biological Chemistry • Jan 28, 2005

Authors:

Yuxin Chen

Colin T. Mant

Susan Walker Farmer

Abstract

In the present study, the 26-residue peptide sequence Ac-KWKSFLKTFKSAVKTVLHTALKAISS-amide (V681) was utilized as the framework to study the effects of peptide hydrophobicity/hydrophilicity, amphipathicity, and helicity (induced by single amino acid substitutions in the center of the polar and nonpol...

Subject

Peptide

Antimicrobial

Chemistry

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