Genetic Variants Associated With Phenytoin-Related Severe Cutaneous Adverse Reactions

Chung, Wen‐Hung; Chang, Wan-Chun; Lee, Yun-Shien; Wu, Ying-Ying; Yang, Chih-Hsun; Ho, Hsin‐Chun; Chen, Ming-Jing; Lin, Jing‐Yi; Chung‐Yee Hui, Rosaline; Ho, Ji-Chen; Wu, Wei-Ming; Chen, Ting-Jui; Wu, Tony; Wu, Yih‐Ru; Hsih, Mo-Song; Tu, Po‐Hsun; Chang, Chen-Nen; Hsu, Chien‐Ning; Wu, Tsu-Lan; Eng Choon, Siew; Hsu, Chao‐Kai; Chen, Der-Yuan; Liu, Chin-San; Lin, Ching-Yuang; Kaniwa, Nahoko; Saito, Yoshiro; Takahashi, Yukitoshi; Nakamura, Ryosuke; Azukizawa, Hiroaki; Shi, Yongyong; Wang, Tzu‐Hao; Chuang, Shiow-Shuh; Tsai, Shih-Feng; Chang, Chee‐Jen; Chang, Yu‐Sun; Chung, Wen‐Hung

doi:10.1001/jama.2014.7859

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Genetic Variants Associated With Phenytoin-Related Severe Cutaneous Adverse Reactions

Published in JAMA • Aug 5, 2014

Authors:

Wen‐Hung Chung

Wan-Chun Chang

Yun-Shien Lee

Abstract

IMPORTANCE: The antiepileptic drug phenytoin can cause cutaneous adverse reactions, ranging from maculopapular exanthema to severe cutaneous adverse reactions, which include drug reactions with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, and toxic epidermal necrolysis. The pharmaco...

Subject

Toxic epidermal necrolysis

Phenytoin

Medicine

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