Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.

Clark Billinghurst, R.; Dahlberg, Leif; Ionescu, Mirela; Reiner, A; Bourne, Roger; H Rorabeck, C; G. Mitchell, Peter; Hambor, John; Diekmann, Oliver; Tschesche, Harald; Chen, J; Van Wart, Harold; Robin Poole, A.

doi:10.1172/jci119316

Public

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.

Published in Journal of Clinical Investigation • Apr 1, 1997

Authors:

R. Clark Billinghurst

Leif Dahlberg

Mirela Ionescu

Abstract

We demonstrate the direct involvement of increased collagenase activity in the cleavage of type II collagen in osteoarthritic human femoral condylar cartilage by developing and using antibodies reactive to carboxy-terminal (COL2-3/4C(short)) and amino-terminal (COL2-1/4N1) neoepitopes generated by c...

Subject

Collagenase

Type II collagen

Cartilage

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