Sca-1 expression identifies stem cells in the proximal region of prostatic ducts with high capacity to reconstitute prostatic tissue

E. Burger, Patricia; Xiong, Xiaozhong; Coetzee, Sandra; N. Salm, Sarah; Moscatelli, David; Goto, Ken; Lynette Wilson, E.

doi:10.1073/pnas.0502761102

Public

Sca-1 expression identifies stem cells in the proximal region of prostatic ducts with high capacity to reconstitute prostatic tissue

Published in Proceedings of the National Academy of Sciences • May 17, 2005

Authors:

Patricia E. Burger

Xiaozhong Xiong

Sandra Coetzee

Abstract

We previously showed that prostatic stem cells are concentrated in the proximal regions of prostatic ducts. We now report that these stem cells can be purified from isolated proximal duct regions by virtue of their high expression of the cell surface protein stem cell antigen 1 (Sca-1). In an in viv...

Subject

Stem cell

Side population

Population

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