Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons.

BACKGROUND: Oxidative stress plays an important role in neuronal dysfunction and neuron loss in Alzheimer's brain. Previous studies have reported downregulation of CREB-mediated transcription by oxidative stress and Aβ. The promoter for CREB itself contains cyclic AMP response elements. Therefore, w... View More