Tumor-Associated Macrophages Regulate Murine Breast Cancer Stem Cells Through a Novel Paracrine EGFR/Stat3/Sox-2 Signaling Pathway

Yang, Jian; Liao, Debbie; Chen, Cong; Liu, Yan; Chuang, Tsung‐Hsien; Xiang, Rong; Markowitz, Dorothy; A. Reisfeld, Ralph; Luo, Yunping

doi:10.1002/stem.1281

Public

Tumor-Associated Macrophages Regulate Murine Breast Cancer Stem Cells Through a Novel Paracrine EGFR/Stat3/Sox-2 Signaling Pathway

Shared by NobleBlocks on Nov 21, 2012 • 12:00 AM UTC

Authors:

Jian Yang

Debbie Liao

Cong Chen

Abstract

The cancer stem cell (CSC) hypothesis has gained significant recognition as a descriptor of tumorigenesis. Additionally, tumor-associated macrophages (TAMs) are known to promote growth and metastasis of breast cancer. However, it is not known whether TAMs mediate tumorigenesis through regulation of ...

Subject

Biology

Paracrine signalling

Cancer research

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