Role of RNA Interference (RNAi) in Dengue Virus Replication and Identification of NS4B as an RNAi Suppressor

Kumar Kakumani, Pavan; S. Ponia, Sanket; K. Shanmugam, Rajgokul; Sood, Vikas; Chinnappan, Mahendran; C. Banerjea, Akhil; R. Medigeshi, Guruprasad; Malhotra, Pawan; Kumar Mukherjee, Sunil; K. Bhatnagar, Raj

doi:10.1128/jvi.02774-12

Public

Role of RNA Interference (RNAi) in Dengue Virus Replication and Identification of NS4B as an RNAi Suppressor

Published in Journal of Virology • Jun 6, 2013

Authors:

Pavan Kumar Kakumani

Sanket S. Ponia

Rajgokul K. Shanmugam

Abstract

RNA interference (RNAi) is an important antiviral defense response in plants and invertebrates; however, evidences for its contribution to mammalian antiviral defense are few. In the present study, we demonstrate the anti-dengue virus role of RNAi in mammalian cells. Dengue virus infection of Huh 7 ...

Subject

RNA interference

Biology

Dicer

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