Inhibition of NADPH oxidase activation in endothelial cells by ortho-methoxy-substituted catechols.

DK, Johnson; KJ, Schillinger; DM, Kwait; CV, Hughes; EJ, McNamara; F, Ishmael; RW, O'Donnell; MM, Chang; MG, Hogg; JS, Dordick; L, Santhanam; LM, Ziegler; JA, Holland

doi:10.1080/10623320213638

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Inhibition of NADPH oxidase activation in endothelial cells by ortho-methoxy-substituted catechols.

Shared by NobleBlocks on Jan 1, 2002 • 12:00 AM UTC

Authors:

Johnson DK

Schillinger KJ

Kwait DM

Abstract

NADPH oxidase is a major enzymatic source of oxygen free radicals in stimulated endothelial cells (ECs). The ortho-methoxy-substituted catechol, apocynin (4-hydroxy-3-methoxyacetophenone), isolated from the traditional medicinal plant Picrorhiza kurroa, inhibits the release of superoxide anion (O2*-...

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