Inhibition of NADPH Oxidase Activation in Endothelial Cells by ortho -Methoxy-Substituted Catechols

K. Johnson, David; J. Schillinger, Kurt; M. Kwait, David; V. Hughes, Chambers; J. McNamara, Erin; Ishmael, Fauod; O’Donnell, Robert; Chang, Ming‐Mei; G. Hogg, Michael; S. Dordick, Jonathan; Santhanam, Lakshmi; M. Ziegler, Linda; A. Holland, James

doi:10.1080/10623320213638

Public

Inhibition of NADPH Oxidase Activation in Endothelial Cells by ortho -Methoxy-Substituted Catechols

Published in Endothelium • Jan 1, 2002

Authors:

David K. Johnson

Kurt J. Schillinger

David M. Kwait

Abstract

NADPH oxidase is a major enzymatic source of oxygen free radicals in stimulated endothelial cells (ECs). The ortho-methoxy-substituted catechol, apocynin (4-hydroxy-3-methoxyacetophenone), isolated from the traditional medicinal plant Picrorhiza kurroa, inhibits the release of superoxide anion (O2*-...

Subject

Apocynin

Chemistry

Superoxide

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