<i>RAS</i>Point Mutations and PAX8-PPARγ Rearrangement in Thyroid Tumors: Evidence for Distinct Molecular Pathways in Thyroid Follicular Carcinoma

N. Nikiforova, Marina; A. Lynch, Roy; W. Biddinger, Paul; K. Alexander, Erik; W. Dorn, Gerald; Tallini, Giovanni; G. Kroll, Todd; E. Nikiforov, Yuri

doi:10.1210/jc.2002-021907

Public

RASPoint Mutations and PAX8-PPARγ Rearrangement in Thyroid Tumors: Evidence for Distinct Molecular Pathways in Thyroid Follicular Carcinoma

Published in The Journal of Clinical Endocrinology & Metabolism • May 1, 2003

Authors:

Marina N. Nikiforova

Roy A. Lynch

Paul W. Biddinger

Abstract

A series of 88 conventional follicular and Hürthle cell thyroid tumors were analyzed for RAS mutations and PAX8-PPAR gamma rearrangements using molecular methods and for galectin-3 and HBME-1 expression by immunohistochemistry. A novel LightCycler technology-based method was developed to detect poin...

Subject

PAX8

Cancer research

Thyroid carcinoma

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