Defective Cardiac Ryanodine Receptor Regulation During Atrial Fibrillation

A. Vest, John; H.T. Wehrens, Xander; Reiken, Steven; E. Lehnart, Stephan; Dobrev, Dobromir; Chandra, Parag; Danilo, Peter; Ravens, Ursula; R. Rosen, Michael; R. Marks, Andrew

doi:10.1161/01.cir.0000162461.67140.4c

Public

Defective Cardiac Ryanodine Receptor Regulation During Atrial Fibrillation

Published in Circulation • Apr 25, 2005

Authors:

John A. Vest

Xander H.T. Wehrens

Steven Reiken

Abstract

BACKGROUND: Ca2+ leak from the sarcoplasmic reticulum (SR) may play an important role in triggering and/or maintaining atrial arrhythmias, including atrial fibrillation (AF). Protein kinase A (PKA) hyperphosphorylation of the cardiac ryanodine receptor (RyR2) resulting in dissociation of the channel...

Subject

Ryanodine receptor 2

Ryanodine receptor

Atrial fibrillation

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