Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease

Li, Zhiping; Yang, Shiqi; Lin, Huizhi; Huang, Jiawen; A. Watkins, Paul; B. Moser, Ann; DeSimone, Claudio; Song, Xiao-yu; Mae Diehl, Anna

doi:10.1053/jhep.2003.50048

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Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease

Shared by NobleBlocks on Feb 1, 2003 • 12:00 AM UTC

Authors:

Zhiping Li

Shiqi Yang

Huizhi Lin

Abstract

Ob/ob mice, a model for nonalcoholic fatty liver disease (NAFLD), develop intestinal bacterial overgrowth and overexpress tumor necrosis factor α (TNF-α). In animal models for alcoholic fatty liver disease (AFLD), decontaminating the intestine or inhibiting TNF-α improves AFLD. Because AFLD and NAFL...

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