Glucocorticoids can induce PTSD-like memory impairments in mice.

N, Kaouane; Y, Porte; M, Vallée; L, Brayda-Bruno; N, Mons; L, Calandreau; A, Marighetto; PV, Piazza; A, Desmedt

doi:10.1126/science.1207615

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Glucocorticoids can induce PTSD-like memory impairments in mice.

Shared by NobleBlocks on Feb 23, 2012 • 12:00 AM UTC

Authors:

Kaouane N

Porte Y

Vallée M

Abstract

Posttraumatic stress disorder (PTSD) is characterized by a hypermnesia of the trauma and by a memory impairment that decreases the ability to restrict fear to the appropriate context. Infusion of glucocorticoids in the hippocampus after fear conditioning induces PTSD-like memory impairments and an a...

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