Neuroprotection from retinal ischemia/reperfusion injury by NOX2 NADPH oxidase deletion.

H, Yokota; SP, Narayanan; W, Zhang; H, Liu; M, Rojas; Z, Xu; T, Lemtalsi; T, Nagaoka; A, Yoshida; SE, Brooks; RW, Caldwell; RB, Caldwell

doi:10.1167/iovs.11-8318

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Neuroprotection from retinal ischemia/reperfusion injury by NOX2 NADPH oxidase deletion.

Shared by NobleBlocks on Oct 11, 2011 • 12:00 AM UTC

Authors:

Yokota H

Narayanan SP

Zhang W

Abstract

Purpose The aim of this study was to determine whether NOX2, one of the homologs of NADPH oxidase, plays a role in neuronal cell death during retinal ischemia.Methods Ischemia reperfusion (I/R) injury was generated in C57/BL6 and NOX2(-/-) mice by increasing the intraocular pressure (IOP) to 110 mm ...

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