Anti-Inflammatory Effects of Flavonoids: Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E1"><mml:mi>κ</mml:mi></mml:math>B Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E2"><mml:mi>κ</mml:mi></mml:math>B Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated Macrophages

Hämäläinen, Mari; Nieminen, Riina; Vuorela, Pia; Heinonen, Marina; Moilanen, Eeva

doi:10.1155/2007/45673

Public

Anti-Inflammatory Effects of Flavonoids: Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF-κB Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF-κB Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated Macrophages

Published in Mediators of Inflammation • Jan 1, 2007

Authors:

Mari Hämäläinen

Riina Nieminen

Pia Vuorela

Abstract

In inflammation, bacterial products and proinflammatory cytokines induce the formation of large amounts of nitric oxide (NO) by inducible nitric oxide synthase (iNOS), and compounds that inhibit NO production have anti-inflammatory effects. In the present study, we systematically investigated the ef...

Subject

Genistein

Isoflavones

Kaempferol

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