Amyloid-like Features of Polyglutamine Aggregates and Their Assembly Kinetics

Chen, Songming; Berthelier, Valérie; Hamilton, John; O'Nuallai, Brian; Wetzel, Ronald

doi:10.1021/bi011772q

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Amyloid-like Features of Polyglutamine Aggregates and Their Assembly Kinetics

Published in Biochemistry • May 17, 2002

Authors:

Songming Chen

Valérie Berthelier

John Hamilton

Abstract

The repeat length-dependent tendency of the polyglutamine sequences of certain proteins to form aggregates may underlie the cytotoxicity of these sequences in expanded CAG repeat diseases such as Huntington's disease. We report here a number of features of various polyglutamine (polyGln) aggregates ...

Subject

Congo red

Fibril

Amyloid (mycology)

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