Synthesis, Characterization, and Bioconjugation of Fluorescent Gold Nanoclusters toward Biological Labeling Applications

J. Lin, Cheng‐An; Yang, Ting‐Ya; Lee, Chih‐Hsien; Huang, Sherry; A. Sperling, Ralph; Zanella, Marco; K. Li, Jimmy; Shen, Ji‐Lin; Wang, Hsueh-Hsiao; Yeh, Hung‐I; J. Parak, Wolfgang; H. Chang, Walter

doi:10.1021/nn800632j

Public

Synthesis, Characterization, and Bioconjugation of Fluorescent Gold Nanoclusters toward Biological Labeling Applications

Published in ACS Nano • Jan 27, 2009

Authors:

Cheng‐An J. Lin

Ting‐Ya Yang

Chih‐Hsien Lee

Abstract

Synthesis of ultrasmall water-soluble fluorescent gold nanoclusters is reported. The clusters have a decent quantum yield, high colloidal stability, and can be readily conjugated with biological molecules. Specific staining of cells and nonspecific uptake by living cells is demonstrated.

Subject

Bioconjugation

Nanoclusters

Fluorescence

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