Translocation of
                    <i>Helicobacter pylori</i>
                    CagA into Gastric Epithelial Cells by Type IV Secretion

Odenbreit, Stefan; Püls, Jürgen; Sedlmaier, Bettina; Gerland, Elke; Fischer, Wolfgang; Haas, Rainer

doi:10.1126/science.287.5457.1497

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Translocation of Helicobacter pylori CagA into Gastric Epithelial Cells by Type IV Secretion

Shared by NobleBlocks on Feb 25, 2000 • 12:00 AM UTC

Authors:

Stefan Odenbreit

Jürgen Püls

Bettina Sedlmaier

Abstract

The Gram-negative bacterium Helicobacter pylori is a causative agent of gastritis and peptic ulcer disease in humans. Strains producing the CagA antigen ( cagA + ) induce strong gastric inflammation and are strongly associated with gastric adenocarcinoma and MALT lymphoma. We show here that such str...

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