Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor

Wallukat, Gerd; Homuth, Volker; Fischer, Thorsten; Lindschau, Carsten; Horstkamp, B.; Jüpner, Axel; Baur, Evi; Nissen, Eberhard; Vetter, K.; Neichel, Dajana; W. Dudenhausen, Joachim; Haller, Hermann; C. Luft, Friedrich

doi:10.1172/jci4106

Public

Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor

Published in Journal of Clinical Investigation • Apr 1, 1999

Authors:

Gerd Wallukat

Volker Homuth

Thorsten Fischer

Abstract

Immune mechanisms and the renin-angiotensin system are implicated in preeclampsia. We investigated 25 preeclamptic patients and compared them with 12 normotensive pregnant women and 10 pregnant patients with essential hypertension. Antibodies were detected by the chronotropic responses to AT1 recept...

Subject

Angiotensin II receptor type 1

Autoantibody

Endocrinology

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