Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome Translocation

Tsujimoto, Yoshihide; R Finger, L; J. Yunis, Jorge; C. Nowell̀, Peter; M. Croce, Carlo

doi:10.1126/science.6093263

Public

Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome Translocation

Published in Science • Nov 30, 1984

Authors:

Yoshihide Tsujimoto

L R Finger

Jorge J. Yunis

Abstract

From an acute B-cell leukemia cell line, a DNA probe was obtained that was specific for chromosome 18 and flanked the heavy chain joining region of the immunoglobulin heavy chain locus on chromosome 14. This probe detected rearrangement of the homologous DNA segment in the leukemic cells and in foll...

Subject

Chromosomal translocation

Biology

Molecular biology

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