Environmental and Heritable Factors in the Causation of Cancer — Analyses of Cohorts of Twins from Sweden, Denmark, and Finland

Lichtenstein, Paul; V. Holm, Niels; K. Verkasalo, Pia; Iliadou, Anastasia; Kaprio, Jaakko; Koskenvuo, Markku; Pukkala, ­Eero; Skytthe, Axel; Hemminki, Kari

doi:10.1056/nejm200007133430201

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Environmental and Heritable Factors in the Causation of Cancer — Analyses of Cohorts of Twins from Sweden, Denmark, and Finland

Published in New England Journal of Medicine • Jul 13, 2000

Authors:

Paul Lichtenstein

Niels V. Holm

Pia K. Verkasalo

Abstract

BACKGROUND: The contribution of hereditary factors to the causation of sporadic cancer is unclear. Studies of twins make it possible to estimate the overall contribution of inherited genes to the development of malignant diseases. METHODS: We combined data on 44,788 pairs of twins listed in the Swed...

Subject

Medicine

Cancer

Heritability

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