Driver mutations in <i>TP53</i> are ubiquitous in high grade serous carcinoma of the ovary

A. Ahmed, Ahmed; Etemadmoghadam, Dariush; Temple, Jillian; G. Lynch, Andy; Riad, Mohamed; Sharma, Raghwa; J.R. Stewart, Colin; Fereday, Sián; Caldas, Carlos; DeFazio, Anna; D.L. Bowtell, David; D. Brenton, James

doi:10.1002/path.2696

Public

Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary

Published in The Journal of Pathology • Feb 3, 2010

Authors:

Ahmed A. Ahmed

Dariush Etemadmoghadam

Jillian Temple

Abstract

Numerous studies have tested the association between TP53 mutations in ovarian cancer and prognosis but these have been consistently confounded by limitations in study design, methodology, and/or heterogeneity in the sample cohort. High-grade serous (HGS) carcinoma is the most clinically important h...

Subject

Ovary

Serous fluid

Serous carcinoma

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