Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation

Kathryn Liszewski, M.; Kolev, Martin; Le Friec, Gaëlle; K. Leung, Marilyn; Bertram, Paula; F. Fara, Antonella; Subías, Marta; C. Pickering, Matthew; Drouet, Christian; Meri, Seppo; Petteri Arstila, T.; T. Pekkarinen, Pirkka; Ma, Margaret; P. Cope, Andrew; Reinheckel, Thomas; Rodrı́guez de Córdoba, Santiago; Afzali, Behdad; P. Atkinson, John; Kemper, Claudia

doi:10.1016/j.immuni.2013.10.018

Public

Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation

Published in Immunity • Dec 1, 2013

Authors:

M. Kathryn Liszewski

Martin Kolev

Gaëlle Le Friec

Abstract

Complement is viewed as a critical serum-operative component of innate immunity, with processing of its key component, C3, into activation fragments C3a and C3b confined to the extracellular space. We report here that C3 activation also occurred intracellularly. We found that the T cell-expressed pr...

Subject

Intracellular

Cell biology

Biology

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