Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis and Inadequate Response to Ursodeoxycholic Acid

M. Hirschfield, Gideon; L. Mason, Andrew; A. Luketic, Velimir; D. Lindor, Keith; C. Gordon, Stuart; J. Mayo, Marlyn; V. Kowdley, Kris; Vincent, Catherine; C. Bodhenheimer, Henry; Parés, Albert; Trauner, Michael; Marschall, Hanns–Ulrich; Adorini, Luciano; Sciacca, Cathi; Beecher-Jones, T.; Castelloe, Erin; Böhm, O.; А. Шапиро, Д.

doi:10.1053/j.gastro.2014.12.005

Public

Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis and Inadequate Response to Ursodeoxycholic Acid

Published in Gastroenterology • Dec 11, 2014

Authors:

Gideon M. Hirschfield

Andrew L. Mason

Velimir A. Luketic

Abstract

BACKGROUND & AIMS: We evaluated the efficacy and safety of obeticholic acid (OCA, α-ethylchenodeoxycholic acid) in a randomized controlled trial of patients with primary biliary cirrhosis who had an inadequate response to ursodeoxycholic acid therapy. METHODS: We performed a double-blind study of 16...

Subject

Ursodeoxycholic acid

Obeticholic acid

Placebo

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