FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

C. Mahon, Patrick; Hirota, Kiichi; L. Semenza, Gregg

doi:10.1101/gad.924501

Public

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

Published in Genes & Development • Oct 15, 2001

Authors:

Patrick C. Mahon

Kiichi Hirota

Gregg L. Semenza

Abstract

Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls angiogenesis, erythropoiesis, and glycolysis via transcriptional activation of target genes under hypoxic conditions. O(2)-dependent binding of the von Hippel-Lindau (VHL) tumor suppressor protein targets th...

Subject

Transactivation

Corepressor

Biology

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