Down-regulation of p27 by Two Mechanisms, Ubiquitin-mediated Degradation and Proteolytic Processing

Shirane, Michiko; Harumiya, Yumiko; Ishida, N.; Hirai, Aizan; Miyamoto, Chikara; Hatakeyama, Shigetsugu; Nakayama, Kei; Kitagawa, Masatoshi

doi:10.1074/jbc.274.20.13886

Public

Down-regulation of p27 by Two Mechanisms, Ubiquitin-mediated Degradation and Proteolytic Processing

Published in Journal of Biological Chemistry • May 1, 1999

Authors:

Michiko Shirane

Yumiko Harumiya

N. Ishida

Abstract

The intracellular level of p27(Kip1), a cyclin-dependent kinase (CDK) inhibitory protein, is rapidly reduced at the G1/S transition phase when the cell cycle pause ceases. In this study, we demonstrated that two posttranslational mechanisms were involved in p27(Kip1) breakdown: degradation via the u...

Subject

Ubiquitin

Ubiquitin-conjugating enzyme

Chemistry

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