Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension

Ranchoux, Benoît; Antigny, Fabrice; Rücker‐Martin, Catherine; Hautefort, Aurélie; Péchoux, Christine; Jan Bogaard, Harm; Dorfmüller, Peter; Remy, Séverine; Lecerf, Florence; Planté, Sylvie; Chat, Sophie; Fadel, Élie; Houssaïni, Amal; Anegón, Ignacio; Adnot, Serge; Simonneau, Gérald; Humbert, Marc; Cohen‐Kaminsky, Sylvia; Perros, Frédéric

doi:10.1161/circulationaha.114.008750

Public

Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension

Published in Circulation • Jan 15, 2015

Authors:

Benoît Ranchoux

Fabrice Antigny

Catherine Rücker‐Martin

Abstract

BACKGROUND: The vascular remodeling responsible for pulmonary arterial hypertension (PAH) involves predominantly the accumulation of α-smooth muscle actin-expressing mesenchymal-like cells in obstructive pulmonary vascular lesions. Endothelial-to-mesenchymal transition (EndoMT) may be a source of th...

Subject

Medicine

Pulmonary hypertension

Mesenchymal stem cell

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