A Prime-Boost Strategy Using Virus-Like Particles Pseudotyped for HCV Proteins Triggers Broadly Neutralizing Antibodies in Macaques

Garrone, Pierre; Fluckiger, Anne-Catherine; Mangeot, Philippe; Gauthier, Emmanuel; Dupeyrot-Lacas, Pia; Mancip, Jimmy; Cangialosi, Arnaud; du Chéné, Isaure; Legrand, R.; Mangeot, Isabelle; Lavillette, Dimitri; Bellier, Bertrand; Cosset, François‐Loïc; Tangy, Frédéric; Klatzmann, David; Dalba, Charlotte

doi:10.1126/scitranslmed.3002330

Public

A Prime-Boost Strategy Using Virus-Like Particles Pseudotyped for HCV Proteins Triggers Broadly Neutralizing Antibodies in Macaques

Published in Science Translational Medicine • Aug 3, 2011

Authors:

Pierre Garrone

Anne-Catherine Fluckiger

Philippe Mangeot

Abstract

Chronic hepatitis C virus (HCV) infection, with its cohort of life-threatening complications, affects more than 200 million persons worldwide and has a prevalence of more than 10% in certain countries. Preventive and therapeutic vaccines against HCV are thus much needed. Neutralizing antibodies (NAb...

Subject

Virology

Neutralizing antibody

Hepatitis C virus

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