Transmission of Hepatitis A to Patients with Hemophilia by Factor VIII Concentrates Treated with Organic Solvent and Detergent To Inactivate Viruses

Mannuccio Mannucci, Pier; Gdovin, Susan; Gringeri, A.; Colombo, Massimo; Mele, Alfonso; Schinaia, Nicola; Ciavarella, N.; U. Emerson, Suzanne; H. Purcell, Robert; Italian Collaborative Group*, and

doi:10.7326/0003-4819-120-1-199401010-00001

Public

Transmission of Hepatitis A to Patients with Hemophilia by Factor VIII Concentrates Treated with Organic Solvent and Detergent To Inactivate Viruses

Published in Annals of Internal Medicine • Jan 1, 1994

Authors:

Pier Mannuccio Mannucci

Susan Gdovin

A. Gringeri

Abstract

OBJECTIVE: To determine whether an outbreak of hepatitis A virus (HAV) infection that occurred in 52 patients with hemophilia in Italy was acquired through infusion of contaminated factor VIII or through environmental enteric transmission. DESIGN: A case-control study and a molecular analysis of HAV...

Subject

Medicine

Jaundice

Virology

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