Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

Lieberman-Aiden, Erez; L. van Berkum, Nynke; Williams, Louise; Imakaev, Maxim; Ragoczy, Tobias; Telling, Agnes; Amit, Ido; R. Lajoie, Bryan; J. Sabo, Peter; O. Dorschner, Michael; Sandstrom, Richard; Bernstein, B; A. Bender, M.; Groudine, Mark; Gnirke, Andreas; Stamatoyannopoulos, J; A. Mirny, Leonid; S. Lander, Eric; Dekker, Job

doi:10.1126/science.1181369

Public

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

Published in Science • Oct 8, 2009

Authors:

Erez Lieberman-Aiden

Nynke L. van Berkum

Louise Williams

Abstract

We describe Hi-C, a method that probes the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing. We constructed spatial proximity maps of the human genome with Hi-C at a resolution of 1 megabase. These maps confirm the presence of ch...

Subject

Genome

Chromosome conformation capture

Biology

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!