The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle.

Gauthier, Charles; Leblais, Véronique; Kobzik, Lester; Trochu, Jean‐Noël; Khandoudi, Nassirah; Bril, Antoine; Balligand, Jean‐Luc; Le Marec, Hervé

doi:10.1172/jci2191

Public

The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle.

Published in Journal of Clinical Investigation • Oct 1, 1998

Authors:

Charles Gauthier

Véronique Leblais

Lester Kobzik

Abstract

Beta1- and beta2-adrenoceptors in heart muscle cells mediate the catecholamine-induced increase in the force and frequency of cardiac contraction. Recently, in addition, we demonstrated the functional expression of beta3-adrenoceptors in the human heart. Their stimulation, in marked contrast with th...

Subject

Contractility

Nitric oxide synthase

Internal medicine

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