DCLK1 Regulates Pluripotency and Angiogenic Factors via microRNA-Dependent Mechanisms in Pancreatic Cancer

M. Sureban, Sripathi; May, Randal; Qu, Dongfeng; Weygant, Nathaniel; Chandrakesan, Parthasarathy; Ali, Naushad; Lightfoot, Stan; Pantazis, Panayotis; V. Rao, Chinthalapally; G. Postier, Russell; W. Houchen, Courtney

doi:10.1371/journal.pone.0073940

Public

DCLK1 Regulates Pluripotency and Angiogenic Factors via microRNA-Dependent Mechanisms in Pancreatic Cancer

Published in PLoS ONE • Sep 9, 2013

Authors:

Sripathi M. Sureban

Randal May

Dongfeng Qu

Abstract

Stem cell pluripotency, angiogenesis and epithelial-mesenchymal transition (EMT) have been shown to be significantly upregulated in pancreatic ductal adenocarcinoma (PDAC) and many other aggressive cancers. The dysregulation of these processes is believed to play key roles in tumor initiation, progr...

Subject

SOX2

Homeobox protein NANOG

Cancer research

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