Inhaled iloprost for severe pulmonary hypertension.

Olschewski, Horst; Simonneau, Gerald; Galiè, Nazzareno; Higenbottam, Timothy; Naeije, Robert; J Rubin, Lewis; Nikkho, Sylvia; Speich, Rudolf; M Hoeper, Marius; Behr, Jürgen; Winkler, Jörg; Sitbon, Olivier; Popov, Wladimir; Ardeschir Ghofrani, H; Manes, Alessandra; G Kiely, David; Ewert, Ralph; Meyer, Andreas; A Corris, Paul; Delcroix, Marion; Gomez-Sanchez, Miguel; Siedentop, Harald; Seeger, Werner; Iloprost Randomized Study Group, Aerosolized

doi:10.1056/nejmoa020204

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Inhaled iloprost for severe pulmonary hypertension.

Published in The New England journal of medicine • Aug 1, 2002

NobleIDark:/48914/w1/20260526/393C7100Record on NobleID

Authors:

Horst Olschewski

,

Gerald Simonneau

,

Nazzareno Galiè

Abstract

BACKGROUND: Uncontrolled studies suggested that aerosolized iloprost, a stable analogue of prostacyclin, causes selective pulmonary vasodilatation and improves hemodynamics and exercise capacity in patients with pulmonary hypertension. METHODS: We compared repeated daily inhalations of 2.5 or 5.0 mi...

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