Inhibition of extracellular HMGB1 attenuates hyperoxia-induced inflammatory acute lung injury

Entezari, Maria; Javdan, Mohammad; J. Antoine, Daniel; M.P. Morrow, Dympna; Sitapara, Ravikumar; Patel, Vivek; Wang, Mao; Sharma, Lokesh; Gorasiya, Samir; Zur, Michelle; Wu, Wenjun; Li, Jian-Hua; Yang, Huan; R. Ashby, Charles; D. Thomas, Douglas; Wang, Haichao; L. Mantell, Lin

doi:10.1016/j.redox.2014.01.013

Public

Inhibition of extracellular HMGB1 attenuates hyperoxia-induced inflammatory acute lung injury

Published in Redox Biology • Jan 1, 2014

Authors:

Maria Entezari

Mohammad Javdan

Daniel J. Antoine

Abstract

Prolonged exposure to hyperoxia results in acute lung injury (ALI), accompanied by a significant elevation in the levels of proinflammatory cytokines and leukocyte infiltration in the lungs. However, the mechanisms underlying hyperoxia-induced proinflammatory ALI remain to be elucidated. In this stu...

Subject

Hyperoxia

HMGB1

Proinflammatory cytokine

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