Human Polymerized Hemoglobin for the Treatment of Hemorrhagic Shock when Blood Is Unavailable: The USA Multicenter Trial

E. Moore, Ernest; A. Moore, Frederick; C. Fabian, Timothy; C. Bernard, Andrew; J. Fulda, Gerard; B. Hoyt, David; M. Duane, Therèse; J. Weireter, Leonard; A. Gómez, Gerardo; Cipolle, Mark; H. Rodman, George; A. Malangoni, Mark; A. Hides, George; Omert, Laurel; A. Gould, Steven

doi:10.1016/j.jamcollsurg.2008.09.023

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Human Polymerized Hemoglobin for the Treatment of Hemorrhagic Shock when Blood Is Unavailable: The USA Multicenter Trial

Published in Journal of the American College of Surgeons • Nov 10, 2008

Authors:

Ernest E. Moore

Frederick A. Moore

Timothy C. Fabian

Abstract

BACKGROUND: Human polymerized hemoglobin (PolyHeme, Northfield Laboratories) is a universally compatible oxygen carrier developed to treat life-threatening anemia. This multicenter phase III trial was the first US study to assess survival of patients resuscitated with a hemoglobin-based oxygen carri...

Subject

Medicine

Adverse effect

Clinical endpoint

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