Expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in various human tumor tissues.

Mori, Kazushige; Hasegawa, Makoto; Nishida, M; Toma, Hideki; Fukuda, Masakatsu; Kubota, Tetsuro; Nagasue, Naofumi; Yamana, Hideaki; H Chung, K; Ikeda, Tomonari; Takasaki, K.; Oka, Masaaki; Kameyama, M; Toi, Makoto; Fujii, Hiroaki; Kitamura, M; Murai, M; Sasaki, Hiroki; Ozono, S.; Makuuchi, H; SHIMADA, Yasuhide; Onishi, Y.; Aoyagi, Sayaka; Mizutani, Kosuke; Ogawa, M; Nakao, Akito; Kinoshita, Hiroki; Tono, Takeshi; Imamoto, H; Nakashima, Yutaka; Manabe, Tatsuya

doi:10.3892/ijo.17.1.33

Public

Expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in various human tumor tissues.

Published in International Journal of Oncology • Jul 1, 2000

Authors:

Kazushige Mori

Makoto Hasegawa

M Nishida

Abstract

Thymidine phosphorylase (dThdPase) is the rate-limiting enzyme that metabolizes 5'-deoxy-5-fluorouridine (5'-dFUrd, doxifluridine), an intermediate metabolite of capecitabine, to the active drug 5-fluorouracil (5-FUra), while dihydropyrimidine dehydrogenase (DPD) catabolizes 5-FUra to an inactive mo...

Subject

Dihydropyrimidine dehydrogenase

Thymidine phosphorylase

Capecitabine

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