Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence

Peyron, Pascale; Vaubourgeix, Julien; Poquet, Yannick; Levillain, Florence; Botanch, Catherine; Bardou, F.; Daffé, Mamadou; Emile, Jean‐François; Marchou, B.; Cardona, Père-Joan; de Chastellier, Chantal; Altare, Frédéric

doi:10.1371/journal.ppat.1000204

Public

Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence

Published in PLoS Pathogens • Nov 11, 2008

Authors:

Pascale Peyron

Julien Vaubourgeix

Yannick Poquet

Abstract

Tuberculosis (TB) is characterized by a tight interplay between Mycobacterium tuberculosis and host cells within granulomas. These cellular aggregates restrict bacterial spreading, but do not kill all the bacilli, which can persist for years. In-depth investigation of M. tuberculosis interactions wi...

Subject

Mycobacterium tuberculosis

Tuberculosis

Microbiology

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