Loss of System x<sub>c</sub><sup>−</sup>Does Not Induce Oxidative Stress But Decreases Extracellular Glutamate in Hippocampus and Influences Spatial Working Memory and Limbic Seizure Susceptibility

De Bundel, Dimitri; Schallier, Anneleen; Loyens, Ellen; Fernando, Ruani; Miyashita, Hirohisa; Van Liefferinge, Joeri; Vermoesen, Katia; Bannai, Shiro; Sato, Hideyo; Michotte, Yvette; Smolders, Ilse; Massie, Ann

doi:10.1523/jneurosci.5465-10.2011

Public

Loss of System xc−Does Not Induce Oxidative Stress But Decreases Extracellular Glutamate in Hippocampus and Influences Spatial Working Memory and Limbic Seizure Susceptibility

Published in Journal of Neuroscience • Apr 13, 2011

Authors:

Dimitri De Bundel

Anneleen Schallier

Ellen Loyens

Abstract

System x(c)- exchanges intracellular glutamate for extracellular cystine, giving it a potential role in intracellular glutathione synthesis and nonvesicular glutamate release. We report that mice lacking the specific xCT subunit of system x(c)- (xCT(-/-)) do not have a lower hippocampal glutathione ...

Subject

Hippocampus

Oxidative stress

Neuroscience

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