Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain

M. House, Colin; E. Kemp, Bruce

doi:10.1126/science.3686012

Public

Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain

Published in Science • Dec 18, 1987

Authors:

Colin M. House

Bruce E. Kemp

Abstract

The regulatory domain of protein kinase C contains an amino acid sequence between residues 19 and 36 that resembles a substrate phosphorylation site in its distribution of basic residue recognition determinants. The corresponding synthetic peptide (Arg19-Phe-Ala-Arg-Lys-Gly-Ala25-Leu-Arg-Gln-Lys-Asn...

Subject

Autophosphorylation

Protein kinase A

Biochemistry

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