Brain Bioavailability of Human Intravenous Immunoglobulin and its Transport through the Murine Blood–Brain Barrier

St‐Amour, Isabelle; Paré, Isabelle; Alata, Waël; Coulombe, Katherine; Ringuette‐Goulet, Cassandra; Drouin‐Ouellet, Janelle; Vandal, Milène; Soulet, Denis; Bazin, Renée; Calon, Frédéric

doi:10.1038/jcbfm.2013.160

Public

Brain Bioavailability of Human Intravenous Immunoglobulin and its Transport through the Murine Blood–Brain Barrier

Published in Journal of Cerebral Blood Flow & Metabolism • Sep 18, 2013

Authors:

Isabelle St‐Amour

Isabelle Paré

Waël Alata

Abstract

Intravenous immunoglobulin (IVIg) is currently evaluated in clinical trials for the treatment of various disorders of the central nervous system. To assess its capacity to reach central therapeutic targets, the brain bioavailability of IVIg must be determined. We thus quantified the passage of IVIg ...

Subject

Blood–brain barrier

Bioavailability

Central nervous system

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