ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol

Mahoney, Emilia; Lucas, David; Gupta, Sneha; J. Wagner, Amy; E. M. Herman, Sarah; L. Smith, Lisa; Yeh, Yuh-Ying; A. Andritsos, Leslie; A. Jones, Jeffrey; M. Flynn, Joseph; A. Blum, Kristie; Zhang, Xiaoli; Lehman, Amy; Kong, Hui; N. Gürcan, Metin; R. Grever, Michael; J. Johnson, Amy; C. Byrd, John

doi:10.1182/blood-2011-12-400184

Public

ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol

Published in Blood • Jun 29, 2012

Authors:

Emilia Mahoney

David Lucas

Sneha Gupta

Abstract

Cyclin dependent kinase (CDK) inhibitors, such as flavopiridol, demonstrate significant single-agent activity in chronic lymphocytic leukemia (CLL), but the mechanism of action in these nonproliferating cells is unclear. Here we demonstrate that CLL cells undergo autophagy after treatment with thera...

Subject

Autophagy

Thapsigargin

Unfolded protein response

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