Functional assignment of KEOPS/EKC complex subunits in the biosynthesis of the universal t 6 A tRNA modification

Perrochia, Ludovic; Guetta, Dorian; Hecker, Arnaud; Forterre, Patrick; Basta, Tamara

doi:10.1093/nar/gkt720

Public

Functional assignment of KEOPS/EKC complex subunits in the biosynthesis of the universal t 6 A tRNA modification

Published in Nucleic Acids Research • Aug 14, 2013

Authors:

Ludovic Perrochia

Dorian Guetta

Arnaud Hecker

Abstract

N(6)-threonylcarbamoyladenosine (t(6)A) is a universal tRNA modification essential for normal cell growth and accurate translation. In Archaea and Eukarya, the universal protein Sua5 and the conserved KEOPS/EKC complex together catalyze t(6)A biosynthesis. The KEOPS/EKC complex is composed of Kae1, ...

Subject

Biology

Methanococcus

Transfer RNA

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