Phosphorothioate-modified oligodeoxyribonucleotides. III. NMR and UV spectroscoptc studies of theRp-Rp,Sp-Sp, andRp-Spduplexes, [d(GGsAATTCC)]2, derived from diastereomericO-ethyl phosphorothioates

A. LaPlanche, Laurine; Leroy James, Thomas; Powell, Cindy; David Wilson, W.; Uznański, Bogdan; J. Stec, Wojciech; F. Summers, Michael; Zon, Gerald

doi:10.1093/nar/14.22.9081

Public

Phosphorothioate-modified oligodeoxyribonucleotides. III. NMR and UV spectroscoptc studies of theRp-Rp,Sp-Sp, andRp-Spduplexes, [d(GGsAATTCC)]2, derived from diastereomericO-ethyl phosphorothioates

Published in Nucleic Acids Research • Jan 1, 1986

Authors:

Laurine A. LaPlanche

Thomas Leroy James

Cindy Powell

Abstract

2D-NOE and 1H NMR chemical shift data obtained for the title oligonucleotides were compared with similar data previously reported [Broido et al. (1985) Eur. J. Biochem. 150, 117-128] for the unmodified "parent" structure, [d(GGAATTCC)]2. The spectroscopically detectable structural perturbations caus...

Subject

Diastereomer

Moiety

Oligonucleotide

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